Blood Transfusion: 350 Years

By Paul Theerman, Associate Director

Three hundred and fifty years ago, on December 17, 1666, the Philosophical Transactions published the first account of blood transfusion, in the form of a letter from physician Richard Lower to chemist Robert Boyle.1 Lower’s experiments transfused blood from one dog to another. The article provided his methods, specifying where the arteries and veins were to be cut, how the quill was to be inserted that formed the blood’s conduit between animals, and many other details of the operation.


Richard Lower (1631-1691), anatomist. Oil painting by Jacob Huysmans. Source: Iconographic Collections, Wellcome Library, London, accessed through Wellcome Images.

In addition to reporting on dog-to-dog transfusions, Lower also mentioned experiments between sheep, and interspecies transfusion between dogs and sheep, alternating donor (“emitter”) and recipient. In this first communication on the subject, Lower also laid out a broad experimental program:

’Tis intended, that these tryals shall be prosecuted to the utmost variety the subject shall beare: As by exchanging the bloud of Old and Young, Sick and Healthy, Hot and Cold, Fierce and Fearful, Lame [i.e., Tame] and Wild Animals, &c. and that not only of the same, but also of differing kinds.

The 1660s were the first heady days of the new Royal Society, whose motto, Nullius in verba (“nothing through words”), was the hallmark of the new “experimental philosophy.” And so these experiments have a bit of the quality of “ringing the changes”: try all kinds of animals, in all kinds of conditions, and see what happens!

Underlying the work, though, was the stronger sense of “blood as medicine.” Seventeenth-century physicians were well aware that too little blood led to death. But more, there was a general notion that blood and health were linked, a notion that came straight out of the humoral tradition. Sanguineous dispositions were healthy ones, in distinction to the melancholic ones that too much black bile created. A balance of humors, of course, was the best, but ruddy blood had an implicit edge.

In the same letter, then, Lower made these observations:

It seems not irrational to guess afore-hand, that the exchange of bloud will not alter the nature or disposition of the Animals, upon which it shall be practiced . . . . The most probable use of this Experiment may be conjectured to be, that one Animal may live with the bloud of another; and consequently that those animals that want bloud, or have corrupt bloud, may be supplied from other with a sufficient quantity, and of such as is good . . . .

Blood transfusion could serve as a type of reverse blood-letting; for those patients with too little blood, more could be supplied, and especially “good” blood rather than “corrupt.” Animals would serve as the blood source without fear that people would take on animal natures.

Human experimentation followed quickly. Similar experiments had been going on in France, and in June 1667, physician Jean-Baptiste Denis undertook the first transfusions into a human. His account, translated and published in the Philosophical Transactions, was called “Touching a Late Cure of an Inveterate Phrensy, by the Transfusion of Blood.”2 Calves’ blood served to restore to his right mind a man under the influence of a “phrensy.” In this case, the animal was chosen for “its mildness and freshness,” in order to temper the blood of the unfortunate—a different understanding from the English!


This image relates more to infusion than to transfusion, that is, placing medicines directly into the body through the bloodstream. The technique lent itself to infusions of blood itself. Source: Johann Daniel Major, Chirurgia infusoria, placidis cl. virorum dubiis impugnata, cum modesta, ad eadem, responsione (Kiloni [Kiel]: Sumptibus Joh. Lüderwald, imprimeb. Joach. Reumannus, 1667), p. 2

On November 23 of that same year, Lower and his colleague, physician Edmund King, transfused sheep’s blood into a Mr. Arthur Coga, also of unsound mind. The transfusion seemed to have a good effect:

The Man after this operation, as well as in it, found himself very well, and hath given in his own Narrative under his own hand, enlarging more upon the benefit, he thinks, he hath received by it, than we think fit to own as yet.3


An image attributed as Lower and King’s 1667 transfusion of Arthur Coga. Source: Matthias Goffried Purmann, Grosser und gantz neugewundener Lorbeer-Krantz, oder Wund Artzney (Frankfort; Leipzig: Widow & heirs of M. Rohrlach, Leignitz, 1705), opposite page 292 of part 3.

But transfusion as a therapy soon petered out. One case in France died. Though Coga survived, he did not fully recover, and he was soon drinking up the 20 shilling fee he received for undertaking the procedure. Blood transfusion was mocked and abandoned in England, and outlawed in France.4

Blood transfusion only revived in the middle of the 19th century, chiefly as a way of restoring blood volume. With the investigation of blood types before World War I, and Rhesus factors before World War II, transfusion became mobilized for war with the establishment of blood banks. In the last half of the 20th century, transfusion from banked blood became standard medical practice in surgeries of all kinds, and (using blood products) for hemophilia.

Suggested Reading:

  1. Holly Tucker, Blood Work: A Tale of Murder and Medicine in the Scientific Revolution (New York: W.W. Norton and Company, 2011).
  2. Anita Guerrini, Experimenting with Animals and Humans: From Galen to Animal Rights (Baltimore: the Johns Hopkins University Press, 2003.)


  1. “The Method Observed in Transfusing the Bloud out of One Animal into Another,” Phil. Trans. 1665-1666 1, 353-358. Accessed November 7, 2016.
  2. “An Extract of a Letter, Written by J. Denis, Doctor of Physick and Professor of Philosophy and Mathematics at Paris, Touching a Late Cure of an Inveterate Phrensy by the Transfusion of Blood,” Phil. Trans. 1666-1667 2, 617-623. Accessed November 7, 2016.
  3. “An Account of the Experiment of Transfusion, Practised upon a Man in London,” Phil. Trans. 1666-1667 2, 557-559. Accessed November 7, 2016.
  4. Elizabeth Yale, “First Blood Transfusion: A History,” JSTOR Daily: Where News Meets Its Scholarly Match, April 22, 2015. Accessed November 7, 2016.

3 thoughts on “Blood Transfusion: 350 Years

  1. Thank you for the nicely written article. Yet, what I found most interesting was the mention to the narrative of the patient and it being recorded by the patient himself. Narrative medicine, along with a paradigm shift to patient-centredness, increasingly regarded as crucial to relevant care, has been emerging in the past few decades, but it is often considered a rather recent development. To see such a mention, along with the emphasis placed upon it, 350 years ago is fascinating to say the least.

    • The narrative is mentioned in the History of the Royal Society, by Thomas Birch (4 vols., London, 1756-1757), 2:216, an account of the society’s meetings. On November 28, 1667: “Mr. Coga . . . presented himself before the society, and produced a Latin paper of his own, giving an account of what he had observed in himself since he underwent the said experiment: which was ordered to be filed up . . . . ” On December 19, having undergone a second transfusion, he reported again (2:227): “Mr. Coga being introduced gave an account of the experiment of transfusion repeated upon him, viz. that he found himself very well at present, though he had been at first somewhat feverish upon it; which was imputed to his excess in drinking too much wine soon after the operation.” Coga’s “Latin paper” seems not to have been published–it would be great to have a longer account of his experience!

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